Utilizing advanced tools and technologies, our doctors take on the toughest cases, providing renewed hope for would-be parents. reviewed by our medical review board and team of experts. Beyond age, the use of certain medications like insulin and corticosteroids can also cause DHEA levels to diminish. I have heard that some women don't respond to DHEA and also some who had a bad cycle on it. Dehydroepiandrosterone (DHEA) is a supplement regularly suggested by doctors for IVF preparation, especially in those women who were previously poor-responders due to diminished ovarian reserve (DOR).A collection of statistical analyses and a few small studies have shown positive outcomes for many women hoping to have a child of their own despite diminished ovarian reserve. So interesting! What is DHEA? Xx, Im from Scotland....not sure where you are. Thoughts? For you guys who is trying supplements and herbs. AMH was ok for my age (over 1) and FSH was... Want to share what I used to help get my periods under control, and my ovulation down to a science.300mg Ubiquinol. I took DHEA all the way to egg collection... 7 follicles instead of the previous rounds of 1 or 2! May or may not work but though it was worth the money whilst I was having NHS treatment. I read online to keep taking it throughout... I’ve been on Dhea to improve egg quality for over a year. I stopped since I chose her to do my 2nd IVF round. We switched to mini IVF to try and get a few higher quality eggs and both times I got 6 follies, 4 eggs, 3 embryos and all were PGS normal for a total of 6 embryos, now 5 on ice. If we end up using donor eggs will defo have it then x. im gonna try and find one if I can - just emailed one x they have halved my medication to get me to try and stimm longer and then up it at the end - having a combination of gonal f and menopur - please let this work !! This time on day 3 my blood test result showed high progesterone levels. Use of this site is subject to our terms of use and privacy policy. I didn’t know I needed to stop them (which is honestly common sense) but I just kept with my normal routine. Have you had any FETs yet? Your body naturally produces the hormone dehydroepiandrosterone (DHEA) in the adrenal gland. In reviewing the studies evaluating DHEA administration, the ones that seem to show no benefit are the studies that administered the DHEA for a very protracted period of time – less than three months often times only during the actual stimulation phase of the IVF cycle. As they are doing the exact same as last time due to low egg reserve, low amh and poor response to the stimms just feel like its going to be the same outcome x, Hi cinder Ella what clinic offers it ? In the trials they have done, they have tended to use a women's previous cycles as controls or women without DOR as controls as the overall results have been great. and do you know your starting DHEA or testosterone numbers? To conclude, DHEA is a powerful hormone and supplement with potential to do a lot of good. Good to hear there have been no side effects. Create an account or log in to participate. So sending you calm vibes. For women with DOR, the generally recommended DHEA dosage for female fertility purposes is 75 mg daily, which is split into three 25mg doses (to keep a stable supply in the body and avoid an upset stomach. What could go wrong and why? He said that there has been some good studies recently with good outcomes and although there was still a lot of research going on that he would personally recommend it from what he has seen. I need your advise on when to stop them during an EPP cycle. Fingers crossed, legs crossed, eyes crossed for you! I unfortunately have lining issues caused by my 2nd D&C (2nd MMC), which means I've had 2 FETs cancelled since then - going for attempt 3 now. To add to this - was it the DHEA? I stopped taking it and on 2-3 days received my period, then restarted it again. My local RE said to stop all supplements before stim except for the prenatal vitamin and fish oil. Diane, Hi button what brand are you taking ? We got none the first collection (July) and have 4 embryo's currently being PGS tested (Sept), so crossing fingers for this!! IVF 1: 10 eggs collected, 4 fertilised normally using ICSI, 1 day 5 embryo, tested PGS abnormal. Unfortunately, DHEA levels drop as you age. Thanks Diane, I am hoping it helps in some way and have to say I haven't experienced any side affects yet...... Hi. I take pregnare vitamin, Royal jelly and a few others. Learn more about. These women underwent IVF before and after DHEA treatment. APPLIED TO THE SKIN : My old RE said I could take DHEA, so I did for 2 weeks while interviewing other clinics, since I knew I’d be leaving my 1st RE due to subpar results with my first IVF. I am still waiting for my appointment. Hope all goes with the ICSI at the end of the month. My energy is low but that’s most likely from the early pregnancy. Micronization means that the individual particles of DHEA have been reduced to very small size. I do think the DHEA has helped as we actually have some good quality day 3 embryo's this time around BUT I'm just crossing fingers they hold out until day 5 and then PGS. At the beginning of the IVF cycle my RE checked progesterone level and based on their value recommended to discontinue DHEA supplement. BTW, I have had a natural child 4 yrs ago, no issues with me or husband, except my age. In 2016, a fertility center from France reported DHEA appeared to improve clinical pregnancy rate by decreasing the cancellation rate in poor responders in IVF. I would get 4 follicles and maybe 1 would fertilize, etc., and never got to transfer. The studies have used micronized DHEA 25 mg three times a day. This means it is naturally made by the body, and it spurs specific tissues or cells into action. As for DHEA, please see below: Dehydroepiandrosterone (DHEA), is steroid hormone produced by the adrenal glands and ovary. I'd already been taking 300mg of Ubiquinol (the active form of CoQ10), plus a heap of other supplements, plus changing my diet etc etc for 6 months prior our first cycle and it did nothing, so I felt I needed to try something new. Typical Dosage for Women with Diminished Ovarian Reserve. Good luck with your 4 embies. This action cannot be undone. The peak dose of DHEA to restore normal levels is 25 milligrams twice daily. But no one really explained to me how it could cause ‘more harm than good’? Side Effects of DHEA My 2nd cycle with the new clinic yielded much better results but that was because of changes in stimm drugs, and by then I was on all advisable supplements for 6mos, etc. DHEA supplementation may be needed for at least 7-10 weeks; Short-term (< 1 year) use of DHEA appears to be safe and well tolerated. However, there are some women who shouldn't take it (e.g. I'll PM you, not sure what I can post on here!x. DHEA is an endogenous steroid hormone. Thanks for that Cinderella5 and that's great you have decided to have it done and fingers crossed it works for you. I took DHEA for 7 weeks before starting my IVF (in vitro fertilization) cycle and stopped when I achieved a positive pregnancy with a HPT. IVF 2: 16 eggs collected, 9 fertilised normally using IVF (not ICSI), waiting for day 5 results, then PGS... Before Transfer. said stop it once you start stims so as not to interfere with the stimulation part of the cycle and your estrogen levels. DHEA levels are found to increase in women until their mid to late 20s and then slowly begin to decline. Experts initially recommended fertility treatments like IVF to be initiated after 6-8 weeks of the DHEA supplementation. I didn't have any side effects but did follow instructions closely- feel free to dm me personally I highly recommend DHEA. Recent studies found that DHEA may also benefit women trying to get pregnant. Thanks xxx, Hi Button-123. x. I know others have posted similar stories, but I wanted to share mine in case it helps someone. I start early May ....  fingers crossed for us both x, Hello, I am taking the dhea eurovital 75mg a day but in 3 doses of 25mg and so far no sides effects. This is also our last NHS go before we start self funding X. I suppose I'm the same lots of eggs buy I think they triggered too early so lots were immature. Hi there, I was just wondering how your second round turned out after having taken DHEA? I usually find I am better going through a stim cycle as I feel like I am actually doing something. Wow you got great results with the DHEA! My current Re is a believer in supplementation with 600 of CQ10, resveratrol, antioxidants, acupuncture, but she does not advise DHEA. DHEA is usually taken for 2 months before starting an IVF cycle. Diane Happy to answer any questions. This conclusion was based on a large cohort of 224 patients comprising of 327 IVF cycles 7 . Anonymous wrote:Are you supposed to stop taking DHEA while stimming? Last time I did Acupunture but I am not going to bother this time. The time between my retrievals was actually pretty calm because I knew what to do and I couldn’t stress about anything else. For women undergoing IVF, DHEA has been shown to improve the numbers of eggs and embryos. In turn, DHEA helps produce other hormones, including testosterone and estrogen. Which is a bit sad, but it is what it is. I am not in favor of using clomiphene in IVF. I am currently taking it in the break between cycles and am curious what to expect. mine wouldn't let me go on it for my first cycle until she'd seen my initial response and when that wasn't great, she gave me a script but was kind of, 'it's unlikely to do any harm, so I'm happy to let you try it'. I had to stim for 13 days on 450 menopur just to get my two ha ha. It is involved in producing the male hormones, androstenedione testosterone and also estrogen. DHEA functions as a biological precursor to androgens … I considered to go on 25 mg of DHAE supplementation, but not unless my FETs fail (I’m 39 and have 2 PGS normal blasts waiting). Research on DHEA and Fertility. I did get pregnant on my own within two weeks, which ended in a chemical a week later. Two months ago i started taking 50mg per day of dhea. If you do want to take any kind of supplements, it’s vital to do so under the right advice. With so many women waiting until their 30s and 40s to have children, there is more emphasis than ever on conceiving in the later years of life. For inability to become pregnant within a year of trying to conceive (infertility): 75 mg of DHEA taken daily for 2-3 months before and during IVF treatment. I didn't feel any different taking either of them - I probably got more energy from changing my diet (going gluten free & eliminating processed sugar). What We Know About DHEA and Fertility. More research is needed - large-scale, considered studies that show beyond any doubt that DHEA actually improves ovarian reserve. My doctor just said to stop if you are pregnant. Moreover, DHEA has been shown to lower FSH levels. Hi Button-123. However, as noted above, the length of time is not necessarily the best indicator--what matters is that the woman’s androgen (testosterone) levels rise to about the upper ⅓ of the normal range. I was also on 600 of CoQ10 and my next cycle I had 6 embryos (good numbers for me) were all 5AB or above and all PGS normal. So I took dhea for 4 months and when I got tested around somewhere in there my levels were in the low/mid normal range. Due to start 2nd round of ICIS at the end of April. Please whitelist our site to get all the best deals and offers from our partners. I am worried because I have been taking my DHEA supplements for almost a week after getting my BFP. We had a retrieval in July (which only resulted in 1 embryo that was abnormal), though I found August (our break month) really stressful, as I ovulated about a week later than normal, so I was wondering will I / won't I and if I don't, how does that affect my next cycle etc etc. I’m glad we did multiple rounds to freeze as many embryos as we could because I’ve never been pregnant before, Never a scare or a miscarriage so we didn’t know how many tries it would take for us to get and stay pregnant. In this cycle, we got 13 eggs, 9 fertilised normally, 4 made it to day 5 and another 2 to day 6 and amazingly, ALL were PGS normal!! My second and current doctor told me to immediately stop taking dhea. However my argument is how do they know implantation isn't a factor ? This could lead to a host of issues in the female body, like loss of libido and the quality of the egg deteriorating. To have all PGS normal is next to unheard of. I am not having it this time but if I get to third go using donor eggs I will defo have it. Peak effectiveness is typically reached between 16 and 20 weeks. DHEA is usually taken for 2 months before starting an IVF cycle. I am trying to stay positive as this is my last go trying with my eggs, if this fails we are going to try donor eggs xxx, Fingers crossed xx r u getting the scratch ... i can't have it as I'm nhs  ! Natural DHEA levels peak in early adulthood and then slowly fall as you age.A synthetic version of DHEA is available for oral use, as a tablet, and a topical cream.Often touted as an anti-aging therapy, DHEA is also claimed to ward off chronic illness and improve physical performance. DHEA is a hormone which occurs naturally in the body and is known to help improve cognitive skills as people age and to slow the progression of Alzheimer’s disease. While waiting for results post egg collection I stopped the DHEA supplementation (basically had a week's break). Oooo that's good to hear. This educational content is not medical or diagnostic advice. Anyone had similar advise to not take it at advanced maternal age? DHEA might be helpful in women with DOR or past poor ovarian response (POR), especially if combined with IVF. I first consulted my RE in February 2018 after 6 months TTC and 1 chemical pregnancy. Good luck! I would check with your consultant to check whether you should keep taking it up until you go for egg collection. 3rd collection - it was only 4 eggs that double fertilised. I stopped taking it about a week before BFP, and my new RE during the interview suggested I stopped since it ‘can do more harm than good’? Yeah! My NHS hospital also doesnt offer it so having it done privately, costing me £225. 7 month old currently sleeping on my tummy . I've recently had my DHEAS level tested and it is double the normal range - 18.9 umol/L (normal range is 1.7 - 9.2 umol/L) and I'm unsure whether I should stop taking this? Though like I said, I've been through the retrieval twice now, the waiting for results, break cycle etc all before so at least I know what to expect, so I'm going to work on being more relaxed (haha 'work on' being relaxed)... We got 4 day 5 embryo's and 2 were normal & 2 were complex abnormal (more than 4 things wrong with them). I would check with your consultant to check whether you should keep taking it up until you go for egg collection. Hence taking the dhea to see if it helps and if it doesn't I am happy to use DE. Congrats! A DHEA fertility study released in July, 2010, conducted by scientists at Tel Aviv University claims that the growth hormone DHEA, or 5-Dehydroepiandrosterone, may increase a woman’s chances of getting pregnant. My previous consultant told me to take it all the way up to egg collection, but my new consultant (who i think is better!) It is important to stress that DHEA must only be taken in consultation with a medical practitioner who can monitor the dosage level. I was almost 34. I am doing the usual healthy eating, exercising, de-caff tea etc. I now have 10 embryos on ice and am in the middle of what we hope to be our last cycle. 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